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The Renaissance-era St Peter's Basilica is one of the largest churches in the world (and the home-church of the Pope). Highlights include the dome (the biggest in the world), Bernini's Baldacchino (the centerpiece of the church), and Michelangelo's Pietà (the only artwork he ever signed).
For both the pious and the casual visitor, a trip to St. Peter's is an awe-inspiring trip into the heart of Vatican City.