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Since it was opened to the public in 1436, Florence's most famous landmark, the Duomo (or Cattedrale di Santa Maria del Fiore) is a must-see city landmark. In fact, its towering size means you can't miss it. Filippo Brunelleschi's red-tiled dome is a wonder all on its own, but the architecture is as impressive inside as it is on the outside. Climbing to the top of this stunning cathedral affords great views of the city.